Amitriptyline Hydrochloride Tablets IP
Each Sugarcoated tablet contains :
Amitriptyline Hydrochloride IP 25 mg
Antidepressants augmented the danger in comparison to placebo of suicidal tendency and behavior in adolescents, children, and young adults in immediate study of major depressive disorders and several other psychiatric diseases. Anyone thinking using of amitriptyline hydrochloride tablets or other antidepressant in an adolescent, child, or young adult must manage this danger with the clinical requirement. Interim studies did not demonstrate a boost in the risk of suicidal tendency with antidepressants in comparison to placebo in adults beyond the age of 24; there was a decrease in danger with antidepressants in comparison to placebo in adults of the age 65 and more than that. Depression and other psychiatric disorders are in themselves linked with the increase in the danger of suicide. Close monitoring of abnormal changes in behavior and observation for clinical deterioration is essential for the patients of all ages on antidepressants. Family members and caretakers are advised to maintain close communication with the prescriber of the medication.
Amitriptyline hydrochloride, an antidepressant has sedative effects. Its method of action on man is still unknown. This medicine does not act basically by promoting the activity of nervous system.
Amitriptyline slows down the membrane pump system that is liable for up taking of serotonin in adrenergic, norepinephrine, and serotonergic neurons. As the re-up taking of biogenic amines is essential physiologically in stopping the transmission activity, pharmacologically this activity may prolong or potentiate neuronal action. This intervention with the re-up take of serotonin or norepinephrine is thought to lie under the antidepressant action of amitriptyline.
For getting relief from the symptoms of depression. There are more chances of endogenous depression to get alleviated than any other type of depressive forms.
Patients with prior hypersensitivity to Amitriptyline hydrochloride are contraindicated for it.
It is restricted to be taken concurrently with monoamine oxidaze inhibitors. Severe convulsions, deaths and Hyper pyretic crisis have been reported in the patients taking monoamine oxidaze inhibiting medicines and tricyclic antidepressants at the same time.
When there is a requirement for the replacement of monoamine inhibitor with amitriptyline hydrochloride, then at least 14 should be taken for the elapse of the former drug. Then Amitriptyline hydrochloride should be initiated gradually and dosage should be increased slowly for receiving the maximum response.
Amitriptyline hydrochloride is not prescribed with Cisapride due to amplified QT interval and danger of arrhythmia.
Also this medicine is not suggested for taking at the time acute recovery after myocardial infarction.
Citi mall, 2nd floor, office no 2B-1/2B-2, New Link Road,, Mumbai, Maharashtra, 400053, India